Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …

The complications of Alzheimer's disease AD were deadly dangerous cause of
neurodegenerative disorders connected with the decline of the cognitive functions and loss …

Coupling of two distinct pharmacophores, tacrine and trolox, endowed with different
biological properties, afforded 21 hybrid compounds as novel multifunctional candidates …

A series of 22 donepezil analogues were synthesized through alkylation/benzylation and
compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be …

Tacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and
butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this …

Alzheimer's disease (AD) is a multifactorial age-related disease associated with oxidative
stress (OS) and impaired cholinergic transmission. Accordingly, targeting mitochondrial OS …

Background: 6-chlorotacrine is a cholinesterase inhibitor showing good inhibitory potential,
even better than parent compound tacrine, in vitro. Despite tacrine scaffold is broadly used …

The number of people suffering from Alzheimer's disease (AD) is expected to increase
dramatically in the coming decades. Currently, acetylcholinesterase inhibitors (AChEis) …

Alzheimer's Disease (AD) is one of the most common forms of dementia in elderly people.
To date, efficacious therapeutic agent for the treatment of AD is still very limited, so it has …

As the number of individuals affected with Alzheimer's disease (AD) increases and the
availability of drugs for AD treatment remains limited, the need to develop effective …