Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of
patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal …

Perturbed neuronal Ca 2+ homeostasis is implicated in age-related cognitive impairment
and Alzheimer's disease (AD). With advancing age, neurons encounter increased oxidative …

During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

The construction of the brain during embryonic development was thought to be largely
independent of its electrical activity. In this view, proliferation, migration and differentiation of …

Accumulating data support the importance of interactions between pre-and postsynaptic
neuronal elements with astroglial processes and extracellular matrix (ECM) for formation …

Apolipoprotein E (ApoE) genotype is a powerful genetic modifier of Alzheimer's disease
(AD). The ApoE4 isoform significantly reduces the mean age-of-onset of dementia through …

Reelin is a glycoprotein that serves important roles both during development (regulation of
neuronal migration and brain lamination) and in adulthood (maintenance of synaptic …

Proper neuronal migration and laminar formation during corticogenesis is essential for
normal brain function. Disruption of these developmental processes is thought to be …