Bioorthogonal click chemistry, first introduced in the early 2000s, has become one of the
most widely used approaches for designing advanced biomaterials for applications in tissue …

A diastereoselective allylation of N-tert-butane sulfinyl α-iminoesters using allylboronic acids
is developed to obtain optically active non-proteinogenic α-amino acid precursors in good …

Proteins with tandem repeats have essential physical or biological roles in cells and have
been widely investigated as biomaterials or vaccines. Chemically derived proteins with …

Oxidative activation of Csingle bondO, Csingle bondN and Csingle bondC bonds has
recently emerged as a powerful method for the synthesis of valuable organic compounds …

Cyanoformamides are prevalent as versatile building blocks for accessing synthetically
useful intermediates and biologically active compounds. The development of a milder …

A novel route of enzalutamide was developed in five steps. Starting from 4-amino-2-
(trifluoromethyl) benzonitrile (7) and Boc-2-aminoisobutyric acid (16), condensation …

One-pot oxime ligation under mild conditions using Pd (II) as a shared catalyst from an
aldehyde precursor (Thz) and a protected aminooxyacetyl group (Proc-Aoa) is reported. Two …

Incorporating unnatural bioorthogonal groups into peptides and proteins offers an excellent
opportunity to endow them with new properties in a precise and controlled manner. Among …