Streptomycetes, soil-dwelling mycelial bacteria that form sporulating aerial branches, have
an exceptionally large number of predicted secreted proteins, including many exported via …

Glycosylation reactions mainly catalyzed by glycosyltransferases (Gts) occur almost
everywhere in the biosphere, and always play crucial roles in vital processes. In order to …

Covering: up to the end of May 2011 Glyco (randomization/diversification) is a term that
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …

Antibiotic resistance poses a tremendous threat to human health. To overcome this problem,
it is essential to know the mechanism of antibiotic resistance in antibiotic-producing and …

In an effort to explore the contribution of the sugar constituents of pharmaceutically relevant
glycosylated natural products, chemists have developed glycosylation methods that are …

Three new members of the angucycline class of antibiotics, pseudonocardones A–C (1–3),
along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) …

Marine microorganisms produce a variety of bioactive secondary metabolites, which
represent a significant source of novel antibiotics. Heterologous expression is a valuable …

The marine Streptomyces sp. CNQ-617 produces two diastereomers, marineosins A and B.
These are structurally related to alkyl prodiginines, but with a more complex cyclization and …

Identifying and understanding the collection of all antibiotic resistance determinants
presented in the global microbiota, the antibiotic resistome, provides insight into the …

To explore the acceptor regioselectivity of OleD-catalyzed glucosylation, the products of
OleD-catalyzed reactions with six structurally diverse acceptors flavones(daidzein) …