p62 links autophagy and Nrf2 signaling

T Jiang, B Harder, MR De La Vega, PK Wong… - Free Radical Biology …, 2015 - Elsevier
Abstract The Nrf2-Keap1-ARE pathway is a redox and xenobiotic sensitive signaling axis
that functions to protect cells against oxidative stress, environmental toxicants, and harmful …

Arsenic contamination of groundwater: a review of sources, prevalence, health risks, and strategies for mitigation

S Shankar, U Shanker, Shikha - The scientific world journal, 2014 - Wiley Online Library
Arsenic contamination of groundwater in different parts of the world is an outcome of natural
and/or anthropogenic sources, leading to adverse effects on human health and ecosystem …

Arsenic exposure and toxicology: a historical perspective

MF Hughes, BD Beck, Y Chen, AS Lewis… - Toxicological …, 2011 - academic.oup.com
The metalloid arsenic is a natural environmental contaminant to which humans are routinely
exposed in food, water, air, and soil. Arsenic has a long history of use as a homicidal agent …

[HTML][HTML] Understanding arsenic toxicity: Implications for environmental exposure and human health

A Garkal, L Sarode, P Bangar, T Mehta… - Journal of Hazardous …, 2024 - Elsevier
Arsenic is a trace element and a metalloid which is prominently known as an environmental
hazard. At present, rising health apprehensions are linked to emanating from a wide array of …

Chelation in metal intoxication

SJS Flora, V Pachauri - … journal of environmental research and public …, 2010 - mdpi.com
Chelation therapy is the preferred medical treatment for reducing the toxic effects of metals.
Chelating agents are capable of binding to toxic metal ions to form complex structures which …

Arsenic and selenium toxicity and their interactive effects in humans

HJ Sun, B Rathinasabapathi, B Wu, J Luo, LP Pu… - Environment …, 2014 - Elsevier
Abstract Arsenic (As) and selenium (Se) are unusual metalloids as they both induce and
cure cancer. They both cause carcinogenesis, pathology, cytotoxicity, and genotoxicity in …

Toxicity testing in the 21st century: a vision and a strategy

D Krewski, D Acosta Jr, M Andersen… - Journal of Toxicology …, 2010 - Taylor & Francis
With the release of the landmark report Toxicity Testing in the 21st Century: A Vision and a
Strategy, the US National Academy of Sciences, in 2007, precipitated a major change in the …

Scientific Opinion on arsenic in food

EFSA Panel on Contaminants in the Food Chain … - Efsa …, 2009 - Wiley Online Library
Abstract The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) assessed
the risks to human health related to the presence of arsenic in food. More than 100,000 …

Arsenic neurotoxicity—a review

A Vahidnia, GB Van der Voet… - Human & experimental …, 2007 - journals.sagepub.com
Arsenic (As) is one of the oldest poisons known to men. Its applications throughout history
are wide and varied: murder, make-up, paint and even as a pesticide. Chronic As toxicity is a …

Liver is a target of arsenic carcinogenesis

J Liu, MP Waalkes - Toxicological sciences, 2008 - academic.oup.com
Inorganic arsenic is clearly a human carcinogen causing tumors of the skin, lung, urinary
bladder, and possibly liver. At the time of construction of this monograph, the evidence for …