Proteins and nucleic acids can phase-separate in the cell to form concentrated biomolecular
condensates,,–. The functions of condensates span many length scales: they modulate …

Fluorescence correlation spectroscopy (FCS) is a well-established technique for studying
dynamic processes and interactions with minimal invasion into the corresponding system …

Proteins are structurally dynamic macromolecules, and it is challenging to quantify the
conformational properties of their native state in solution. Nanopores can be efficient tools to …

We present the recent developments and advances in fluorescence correlation
spectroscopy (FCS) and their application to the investigation of biomolecular conformations …

Molecular motion of biopolymers in vivo is known to be strongly influenced by the high
concentration of organic matter inside cells, usually referred to as crowding conditions. To …

Therapeutic antibodies administered intravitreally are the current standard of care to treat
retinal diseases. The ocular half-life (t 1/2) is a key determinant of the duration of target …

Macromolecular crowding (MMC) in cells is a hot topic in biology; therefore, well-
characterized measurement standards for the evaluation of the nano-environment in MMC …

Many biological macromolecules can phase-separate in the cell and form highly
concentrated condensates. The mesoscopic dynamics of these assemblies have been …

Diffusive motion accompanies many physical and biological processes. The Stokes–
Sutherland–Einstein relation for the translational diffusion coefficient, DT, agrees with …

The electronic propensity rule, which suggests a proportional relationship between radiative
and nonradiative electronic coupling elements in fluorescent molecules, has been …