webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study
The development of transcriptome-wide association studies (TWAS) has enabled
researchers to better identify and interpret causal genes in many diseases. However, there …
researchers to better identify and interpret causal genes in many diseases. However, there …
The 27th annual Nucleic Acids Research database issue and molecular biology database collection
DJ Rigden, XM Fernández - Nucleic Acids Research, 2020 - academic.oup.com
Abstract The 2020 Nucleic Acids Research Database Issue contains 148 papers spanning
molecular biology. They include 59 papers reporting on new databases and 79 covering …
molecular biology. They include 59 papers reporting on new databases and 79 covering …
WebCSEA: web-based cell-type-specific enrichment analysis of genes
Human complex traits and common diseases show tissue-and cell-type-specificity. Recently,
single-cell RNA sequencing (scRNA-seq) technology has successfully depicted cellular …
single-cell RNA sequencing (scRNA-seq) technology has successfully depicted cellular …
scGWAS: landscape of trait-cell type associations by integrating single-cell transcriptomics-wide and genome-wide association studies
Background The rapid accumulation of single-cell RNA sequencing (scRNA-seq) data
presents unique opportunities to decode the genetically mediated cell-type specificity in …
presents unique opportunities to decode the genetically mediated cell-type specificity in …
MicroRNA expression in extracellular vesicles as a novel blood‐based biomarker for Alzheimer's disease
INTRODUCTION Brain cell–derived small extracellular vesicles (sEVs) in blood offer unique
cellular and molecular information related to the onset and progression of Alzheimer's …
cellular and molecular information related to the onset and progression of Alzheimer's …
Scoring functions for drug-effect similarity
S Struckmann, M Ernst, S Fischer, N Mah… - Briefings in …, 2021 - academic.oup.com
Motivation The difficulty to find new drugs and bring them to the market has led to an
increased interest to find new applications for known compounds. Biological samples from …
increased interest to find new applications for known compounds. Biological samples from …
A gene regulatory network approach harmonizes genetic and epigenetic signals and reveals repurposable drug candidates for multiple sclerosis
Multiple sclerosis (MS) is a complex dysimmune disorder of the central nervous system.
Genome-wide association studies (GWAS) have identified 233 genetic variations associated …
Genome-wide association studies (GWAS) have identified 233 genetic variations associated …
Retinal disease projection conditioning by biological traits
Fundus image captures rear of an eye which has been studied for disease identification,
classification, segmentation, generation, and biological traits association using handcrafted …
classification, segmentation, generation, and biological traits association using handcrafted …
DeepFun: a deep learning sequence-based model to decipher non-coding variant effect in a tissue-and cell type-specific manner
More than 90% of the genetic variants identified from genome-wide association studies
(GWAS) are located in non-coding regions of the human genome. Here, we present a user …
(GWAS) are located in non-coding regions of the human genome. Here, we present a user …
deCS: A Tool for Systematic Cell Type Annotations of Single-Cell RNA Sequencing Data Among Human Tissues
Single-cell RNA sequencing (scRNA-seq) is revolutionizing the study of complex and
dynamic cellular mechanisms. However, cell type annotation remains a main challenge as it …
dynamic cellular mechanisms. However, cell type annotation remains a main challenge as it …