NOD1 and NOD2 are related intracellular sensors of bacterial peptidoglycan and belong to
the Nod-like receptor (NLR) family of innate immune proteins that play fundamental and …

The aetiology and pathogenesis of inflammatory bowel disease (IBD) remains unclear but
involves a complex interplay between genetic risk, environmental exposures, the immune …

Regeneration of epithelia is crucial for maintaining the intestinal barrier and homeostasis.
Our previous work showed that exopolysaccharides from Lactobacillus plantarum NCU116 …

As an intracellular pattern recognition receptor (PPR), the nucleotide-binding
oligomerization domain-containing protein 2 (NOD2) triggers a cascade of immune …

Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition
receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host …

Mutations in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) cause
Blau syndrome, an inflammatory disorder characterized by uveitis. The antimicrobial …

Macropinocytosis is essential for myeloid cells to survey their environment and for growth of
RAS-transformed cancer cells. Several growth factors and inflammatory stimuli are known to …

Despite advances in immunosuppressive prophylaxis and overall supportive care,
gastrointestinal (GI) graft-versus-host disease (GVHD) remains a major, lethal side effect …

The breakdown of the intestinal mucosal barrier is thought to underlie the progression to
Crohn disease (CD), whereby numerous risk factors contribute. For example, a genetic …

Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular pattern recognition
receptor (PRR) responsible for sensing bacterial peptidoglycan fragments. Stimulation of …