Emerging evidence links the growth hormone (GH)-insulin-like growth factor-1 (IGF1)
endocrine axis to cancer development. While this putative correlation is of major …

Signalling pathways in endometrial cancer Page 1 Carcinogenesis is a multistage process,
during which the activity of sig nalling pathways responsible for cell cycle regulation and …

Accumulating epidemiological evidence shows that obesity is associated with an increased
risk of several types of adult cancers, including endometrial cancer. Chronic …

Introduction: The insulin-like growth factors (IGFs) are a family of secreted peptide hormones
with important roles in different cellular and organism functions. The biological activities of …

Epidemiological as well as clinical and experimental data identified the insulin-like growth
factors (IGF1, IGF2) as important players in gynecological cancers in general, and …

Endometrial carcinoma (EC) is the most common gynecologic malignancy in the United
States. Prognosis depends on patient age, histological grade, depth of myometrial invasion …

Laron syndrome (LS) is a rare genetic endocrinopathy that results from mutation of the
growth hormone receptor (GH-R) gene and is typically associated with dwarfism and …

Introduction: The signaling pathways of the insulin-like growth factors (IGF) have been
implicated in the etiology of a number of epithelial neoplasms including prostate, breast …

The insulin-like growth factor (IGF) system has a direct effect on cellular proliferation and
survival, and interacts with genetic and environmental factors implicated in causing cancer …

Clinical, epidemiological, and experimental evidence indicate that the insulin-like growth
factors (IGFs) are important mediators in the biochemical chain of events that lead from a …