Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …

Practitioners of ancient societies from the time of Hippocrates and earlier recognized and
treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or …

Inflammation is an immune response that works as a contained fire that is pre-emptively
sparked as a defensive process during infections or upon any kind of tissue insult, and that …

Specialized pro-resolving mediators (SPMs) are enzymatically derived from essential fatty
acids and have important roles in orchestrating the resolution of tissue inflammation—that is …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion
injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro …

Mounting of the acute inflammatory response is crucial for host defense and pivotal to the
development of chronic inflammation, fibrosis, or abscess formation versus the protective …

The acute inflammatory response is host-protective to contain foreign invaders. Many of
today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious …

Microglia are resident brain macrophages that become inflammatory activated in most brain
pathologies. Microglia normally protect neurons, but may accidentally kill neurons when …