Chimeric antigen receptor (CAR)-T cell therapy demonstrates substantial efficacy in various
hematological malignancies. However, its application in solid tumors is still limited. Clinical …

Human epidermal growth factor receptor 2 (HER2)+ gastric cancer (GC) is a distinct subtype
of GC, accounting for 10‑20% of all cases of GC. Although the development of the anti‑HER2 …

We present the preclinical pharmacology of BNT142, a lipid nanoparticle (LNP)–formulated
RNA (RNA-LNP) encoding a T cell–engaging bispecific antibody that monovalently binds …

Esophageal adenocarcinoma (EAC) is one of the deadliest tumor entities worldwide, with a
5-year survival rate of less than 25%. Unlike other tumor entities, personalized therapy …

Background The histone gene H2AX and its phosphorylated protein γ-H2AX play a crucial
role in the DNA damage response. This study investigates the expression of H2AX mRNA …

Purpose Hepatocellular carcinoma (HCC) is one of the most lethal malignancies in the
world. Oncofetal proteins are the optimal diagnostic biomarkers and therapeutic targets for …

Claudins, a family of tetraspan transmembrane proteins, are critical to the integrity of tight
junctions in epithelia and endothelia, influencing cellular processes such as development …

Esophageal and gastric malignancies are 2 of the leading causes of cancer deaths
worldwide, ranking sixth and fourth, respectively, in overall mortality. 1, 2 Five-year survival …

АННОТАЦИЯ В данном обзоре представлены сведения о белках плотных
межклеточных контактов клаудинах и их роли в патогенезе и терапии злокачественных …

This review provides information about the proteins of dense intercellular contacts of
claudines and their role in the pathogenesis and therapy of malignant neoplasms. Special …