Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …

Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation
of action potentials in excitable cells. VGSCs in mammalian brain are heterotrimeric …

Voltage-gated Na+ channels (VGSCs) are macromolecular protein complexes containing a
pore-forming α subunit and smaller non-pore-forming β subunits. VGSCs are expressed in …

Abstract High-fat diet (HFD)-induced obesity is associated with not only increased risk of
metabolic and cardiovascular diseases, but cognitive deficit, depression and anxiety …

Abstract Voltage-gated Na+ channels (VGSCs) are heteromeric membrane protein
complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits …

A wide body of evidence suggests that voltage-gated sodium channels (VGSCs) are
expressed de novo in several human carcinomas where channel activity promotes a variety …

Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential
for proper electrical conduction within the heart. Both acquired conditions associated with …

The degradation of the extracellular matrix by cancer cells represents an essential step in
metastatic progression and this is performed by cancer cell structures called invadopodia …

Cancer cells feature a resting membrane potential (V m) that is depolarized compared to
normal cells, and express active ionic conductances, which factor directly in their …