Nutritional intake is a fundamental determinant of health. Many studies have correlated
excess caloric intake, as well as a high ratio of n-6: n-3 fatty acids, with detrimental health …

AIM: To investigate the contribution of polymorphisms in nuclear receptors to risk of
inflammatory bowel disease (IBD). METHODS: Genotypes of nuclear factor (NF)-κB (NFKB1) …

Interest in grape seed proanthocyanidin (GSP) as a cholesterol-lowering nutraceutical is
growing. This study was to investigate the effect of GSP on blood cholesterol level and gene …

Cyclosporine A (CsA) is an efficient immunosuppressant used for reducing allograft rejection
but with a severe side effect of causing hypertension. We hypothesize that the renal …

Although the main role of P-glycoprotein (Pgp) is to extrude a broad range of xenochemicals
and to protect the organism against xenotoxicity, it also transports a large range of …

Disturbances on lipid metabolism are associated with health disorders. High-fat diets (HFDs)
consumption promotes cardiovascular and neurodegenerative diseases where cholesterol …

BACKGROUND: While involvement of ABCB1 is well known in drug transport, its metabolite
transport role is not so well understood. Like other ABC transporters, ABCB1 might be …

Aims Stress response, in terms of activation of stress factors, is known to cause obesity and
coronary heart disease such as atherosclerosis in human. However, the underlying …

Diabetes Mellitus has appeared as a universal burden. Studies have reported that mortality
from Coronary Heart Disease (CHD) in diabetic patients is 2-4 times higher than …

Many people believe that opium has beneficial effects on lipid profile which results in
reduced atherosclerosis. Opium contains several alkaloids and biological active …