The metabolic face of migraine—from pathophysiology to treatment

EC Gross, M Lisicki, D Fischer, PS Sándor… - Nature Reviews …, 2019 - nature.com
Migraine can be regarded as a conserved, adaptive response that occurs in genetically
predisposed individuals with a mismatch between the brain's energy reserve and workload …

Nutrients to improve mitochondrial function to reduce brain energy deficit and oxidative stress in migraine

M Fila, C Chojnacki, J Chojnacki, J Blasiak - Nutrients, 2021 - mdpi.com
The mechanisms of migraine pathogenesis are not completely clear, but 31P-nuclear
magnetic resonance studies revealed brain energy deficit in migraineurs. As glycolysis is the …

Potential protective mechanisms of ketone bodies in migraine prevention

EC Gross, RJ Klement, J Schoenen, DP D'Agostino… - Nutrients, 2019 - mdpi.com
An increasing amount of evidence suggests that migraines are a response to a cerebral
energy deficiency or oxidative stress levels that exceed antioxidant capacity. The ketogenic …

Metabolic aspects of migraine: association with obesity and diabetes mellitus

E Rivera-Mancilla, L Al-Hassany, CM Villalón… - Frontiers in …, 2021 - frontiersin.org
Migraine is a disabling neurovascular disorder, characterized by moderate to severe
unilateral headaches, nausea, photophobia, and/or phonophobia, with a higher prevalence …

Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine

EC Gross, N Putananickal, AL Orsini, DR Vogt… - Scientific Reports, 2021 - nature.com
Increasing evidence points towards the role of mitochondrial functioning, energy
metabolism, and oxidative stress in migraine. However not all previous research has been …

Is migraine primarily a metaboloendocrine disorder?

I Rainero, F Govone, A Gai, A Vacca… - Current pain and headache …, 2018 - Springer
Abstract Purpose of the Review The goals of this review are to evaluate recent studies
regarding comorbidity between migraine and different metabolic and endocrine disorders …

The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines

MR Kelishadi, AA Naeini, F Khorvash, G Askari… - Scientific reports, 2022 - nature.com
The current study was performed to evaluate the effects of alpha-lipoic acid (ALA)
supplementation on lactate, nitric oxide (NO), vascular cell adhesion molecule-1 (VCAM-1) …

Experimental and clinical evidence of the effectiveness of riboflavin on migraines

G Yamanaka, S Suzuki, N Morishita, M Takeshita… - Nutrients, 2021 - mdpi.com
Riboflavin, a water-soluble member of the B-vitamin family, plays a vital role in producing
energy in mitochondria and reducing inflammation and oxidative stress. Migraine …

Practical supplements for prevention and management of migraine attacks: a narrative review

Z Hajhashemy, S Golpour-Hamedani… - Frontiers in …, 2024 - frontiersin.org
Background Migraine is one of the most debilitating neurological disorders that causes
frequent attacks of headaches and affects approximately 11% of the global population …

Defining metabolic migraine with a distinct subgroup of patients with suboptimal inflammatory and metabolic markers

EC Gross, N Putananickal, AL Orsini, J Schoenen… - Scientific reports, 2023 - nature.com
Emerging evidence suggest migraine is a response to cerebral energy deficiency or
oxidative stress in the brain. Beta-hydroxybutyrate (BHB) is likely able to circumvent some of …