Osteopetrosis is a genetic condition of increased bone mass, which is caused by defects in
osteoclast formation and function. Both autosomal recessive and autosomal dominant forms …

Proton pump inhibitors (PPIs) marked a before and after in the management of gastric acid‐
related disorders since their introduction to the market in 1989. Due to a novel, highly …

Current clinical approaches to osteoporosis primarily target osteoclast biology, overlooking
the synergistic role of bone cells, immune cells, cytokines, and inorganic components in …

Osteoporosis is characterized by an alteration of bone microstructure with a decreased bone
mineral density, leading to the incidence of fragility fractures. Around 200 million people are …

The mouse genetic revolution has shown repeatedly that most organs have more functions
than expected. This has led to the realization that, in addition to a molecular and cellular …

Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there
are concerns about overuse and the numerous reported side-effects. It is uncertain whether …

Calcium and vitamin D are essential for maintaining bone health. Therefore, deficiencies in
calcium and vitamin D are major risk factors for osteoporosis development. Because …

The skeleton is a dynamic tissue continuously adapting to mechanical stimuli. Although
matrix‐embedded osteocytes are considered as the key mechanoresponsive bone cells, all …

Cathepsin K (CTSK) is secreted by osteoclasts to degrade collagen and other matrix
proteins during bone resorption. Global deletion of Ctsk in mice decreases bone resorption …

The skeleton has recently emerged as an endocrine organ implicated in the regulation of
glucose and energy metabolism. This function of bone is mediated, at least in part, by …