The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Posttranslational modifications of histones (PTMs) are associated with specific chromatin
and gene expression states,. Although studies in Drosophila melanogaster have revealed …

Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

Histone-modifying enzymes are implicated in the control of diverse DNA-templated
processes including gene expression. Here, we outline historical and current thinking …

The oocyte epigenome plays critical roles in mammalian gametogenesis and
embryogenesis. Yet, how it is established remains elusive. Here, we report that histone …

Myriads of epigenomic features have been comprehensively profiled in health and disease
across cell types, tissues and individuals. Although current epigenomic approaches can …

Abstract Polycomb group (PcG) and Trithorax group (TrxG) genes encode important
regulators of development and differentiation in metazoans. These two groups of genes …

INTRODUCTION Animal development depends on the capacity of cells to respond to
transient spatial and temporal cues by establishing heritable states of gene expression that …

Though cell size varies between different cells and across species, the nuclear-to-
cytoplasmic (N/C) ratio is largely maintained across species and within cell types. A cell …