Recombinant adeno-associated virus (AAV) vectors have been, or are currently in use, in
332 phase I/II/III clinical trials in a number of human diseases, and in some cases …

Cancer stem cells (CSCs) are a major hindrance to clinical cancer treatment. Owing to their
high tumorigenic and metastatic potential, CSCs are vital in malignant tumor initiation …

Protein aggregation causes a wide range of neurodegenerative diseases. Targeting and
removing aggregates, but not the functional protein, is a considerable therapeutic challenge …

Adeno-associated virus (AAV) mediated gene therapy is a leading gene delivery platform
with potential to transform the landscape of treatment for neurological disorders. While AAV …

One of the well-known X-linked genetic disorders is hemophilia, which could be hemophilia
A as a result of a mutation in the F8 (factor VIII) gene or hemophilia B as a result of a …

Hearing loss stands as the most prevalent sensory deficit among humans, posing a
significant global health challenge. Projections indicate that by 2050, approximately 10% of …

Hearing loss is the most common sensory deficit experienced by humans and represents
one of the largest chronic health conditions worldwide. It is expected that around 10% of the …

Chronic kidney disease (CKD) poses a significant global health challenge, projected to
become one of the leading causes of death by 2040. Current treatments primarily manage …

BACKGROUND: Duchenne muscular dystrophy (DMD) is a rare, degenerative, recessive X-
linked neuromuscular disease. Mutations in the gene encoding dystrophin lead to the …

Hyperlipidemia is a medical condition characterized by high levels of lipids in the blood. It is
often associated with an increased risk of cardiovascular diseases such as heart attacks and …