The drug-induced long QT syndrome is a distinct clinical entity that has evolved from an
electrophysiologic curiosity to a centerpiece in drug regulation and development. This …

Purpose: To integrate information from the various disciplines that contribute to the
understanding of the cause and prevention of sudden cardiac death: identification of new …

The epidemiology of ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death
(SCD) must be explored from multiple aspects, each of which contributes insights into the …

Recent studies have described regional differences in the electrophysiology and
pharmacology of ventricular myocardium in canine, feline, rat, guinea pig, and human …

Class III antiarrhythmic agents act by selective prolongation of cardiac action potential
duration (APD). Methanesulfonanilide class III agents (eg, E-4031 and dofetilide) are …

With regard to currently available class III agents, although their class III effect may reduce
the likelihood of tachycardia initiation, their reverse use-dependent prolongation of action …

Marked QT prolongation and torsades de pointes can occur not only in the congenital long
QT syndromes (LQTSs) but also as a consequence of environmental stimuli, notably …

One of the most pronounced gender-based differences in response to drugs is women's far
greater risk of developing the life-threatening ventricular arrhythmia called torsades de …

The mechanism by which isoproterenol (ISO) prevents the prolongation of action potential
duration (APD) and refractory period (RP) by the class III antiarrhythmic agent E-4031 was …

Objectives: The aim of this study was to describe a new familial cardiac phenotype and to
elucidate the electrophysiological mechanism responsible for the disease. Background …