Generating force and movement is essential for the functions of cells and organisms. A
variety of molecular motors that can move on tracks within cells have evolved to serve this …

Muscles are essential for movement and heart function. Contraction and relaxation of
muscles rely on the sliding of two types of filaments—the thin filament and the thick myosin …

Actin undergoes structural transitions during polymerization, ATP hydrolysis, and
subsequent release of inorganic phosphate. Several actin-binding proteins sense specific …

Actin filaments (F-actin) are a key component of eukaryotic cells. Whether serving as a
scaffold for myosin or using their polymerization to push onto cellular components, their …

The actin cytoskeleton mediates mechanical coupling between cells and their tissue
microenvironments. The architecture and composition of actin networks are modulated by …

We present a correlation-driven molecular dynamics (CDMD) method for automated
refinement of atomistic models into cryo-electron microscopy (cryo-EM) maps at resolutions …

Human atrial and ventricular contractions have distinct mechanical characteristics including
speed of contraction, volume of blood delivered and the range of pressure generated …

Oligomeric proteins are central to cellular life and the duplication and divergence of their
genes is a key driver of evolutionary innovations. The duplication of a gene coding for an …

Heart contraction depends on a complicated array of interactions between sarcomeric
proteins required to convert chemical energy into mechanical force. Cyclic interactions …

Actin is a widely expressed protein found in almost all eukaryotic cells. In humans, there are
six different genes, which encode specific actin isoforms. Disease-causing mutations have …