Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …

Elucidating the biology of yeast in its full complexity has major implications for science,
medicine and industry. One of the most critical processes determining yeast life and …

Yeast and cancer cells share the unusual characteristic of favoring fermentation of sugar
over respiration. We now reveal an evolutionary conserved mechanism linking fermentation …

A cell's decision to die is controlled by a sophisticated network whose deregulation
contributes to the pathogenesis of multiple diseases including neoplastic and …

Yeasts, such as Saccharomyces cerevisiae, have long served as useful models for the study
of oxidative stress, an event associated with cell death and severe human pathologies. This …

During the past years, yeast has been successfully established as a model to study
mechanisms of apoptotic regulation. However, the beneficial effects of such a cell suicide …

Acetic acid stress represents a frequent challenge to counteract for yeast cells under several
environmental conditions and industrial bioprocesses. The molecular mechanisms …

The molecular mechanisms that cause organismal aging are a topic of intense scrutiny and
debate. Dietary restriction extends the life span of many organisms, including yeast, and …

Silver nanoparticles have been shown to be detrimental to fungal cells although the
mechanism (s) of action have not been clearly established. In this study, we used Candida …

In vitro–in vivo extrapolation (IVIVE) analyses translating high-throughput screening (HTS)
data to human relevance have been limited. This study represents the first report applying …