Technological advances and clinical research over the past few decades have given
radiation oncologists the capability to personalize treatments for accurate delivery of …

Radiobiological research over the past decades has provided evidence that cancer stem
cell content and the intrinsic radiosensitivity of cancer stem cells varies between tumours …

Radiotherapy and chemotherapy are given in multiple doses, which are spaced out to allow
the recovery of normal tissues between treatments. However, surviving cancer cells also …

A paradigm shift from current population based medicine to personalized and participative
medicine is underway. This transition is being supported by the development of clinical …

The tumor microenvironment is increasingly recognized as a major factor influencing the
success of therapeutic treatments and has become a key focus for cancer research. The …

Purpose: Cancer is a multigene disease which arises as a result of mutational and
epigenetic changes coupled with activation of complex signaling networks. The use of …

Two mechanisms of radiotherapy resistance which are of major importance in various
tumour types are tumour-cell repopulation and hypoxia. ARCON (accelerated radiotherapy …

Purpose: To investigate the impact of hypoxia-induced gene expression and cancer stem
cell (CSC) marker expression on outcome of postoperative cisplatin-based …

Purpose To determine whether increased duration of radiation therapy (RT) and overall
treatment (RX) time has a detrimental effect in anal cancer. Patients and Methods Data from …

Accelerated tumor cell proliferation is an important mechanism adversely affecting
therapeutic outcome in head and neck cancer. 3′-deoxy-3′-18F-fluorothymidine (18F …