The key role of lysosomal protease cathepsins in viral infections
M Scarcella, D d'Angelo, M Ciampa, S Tafuri… - International journal of …, 2022 - mdpi.com
Cathepsins encompass a family of lysosomal proteases that mediate protein degradation
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …
The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor
ABSTRACT Coronavirus disease 2019 (COVID-19) is an ongoing pandemic that lacks
effective therapeutic interventions. SARS-CoV-2 infects ACE2-expressing cells and gains …
effective therapeutic interventions. SARS-CoV-2 infects ACE2-expressing cells and gains …
[HTML][HTML] Future trajectory of SARS-CoV-2: constant spillover back and forth between humans and animals
Abstract SARS-CoV-2, known as severe acute respiratory syndrome coronavirus 2, is
causing a massive global public health dilemma. In particular, the outbreak of the Omicron …
causing a massive global public health dilemma. In particular, the outbreak of the Omicron …
Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is a major public health issue. The spike (S) protein mutation …
coronavirus 2 (SARS-CoV-2) is a major public health issue. The spike (S) protein mutation …
Comparative evaluation of authorized drugs for treating Covid‐19 patients
Abstract Background and Aims Vaccines are the first line of defense against coronavirus
disease 2019 (Covid‐19). However, the antiviral drugs provide a new tool to fight the Covid …
disease 2019 (Covid‐19). However, the antiviral drugs provide a new tool to fight the Covid …
SARS‐CoV‐2 biology and variants: anticipation of viral evolution and what needs to be done
The global propagation of SARS‐CoV‐2 and the detection of a large number of variants,
some of which have replaced the original clade to become dominant, underscores the fact …
some of which have replaced the original clade to become dominant, underscores the fact …
Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides
SARS-CoV-2 Spike protein RBD interacts with the hACE2 receptor to initiate cell entry and
infection. We set out to develop lactam-based i, i+ 4 stapled hACE2 peptides targeting SARS …
infection. We set out to develop lactam-based i, i+ 4 stapled hACE2 peptides targeting SARS …
[HTML][HTML] Microsecond MD simulation and multiple-conformation virtual screening to identify potential anti-COVID-19 inhibitors against SARS-CoV-2 main protease
The recent pandemic outbreak of COVID-19, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), raised global health and economic concerns …
coronavirus 2 (SARS-CoV-2), raised global health and economic concerns …
miR-142 targets TIM-1 in human endothelial cells: potential implications for stroke, COVID-19, Zika, Ebola, Dengue, and other viral infections
T-cell immunoglobulin and mucin domain 1 (TIM-1) has been recently identified as one of
the factors involved in the internalization of the severe acute respiratory syndrome …
the factors involved in the internalization of the severe acute respiratory syndrome …
Brilacidin, a COVID‐19 drug candidate, demonstrates broad‐spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both …
Brilacidin, a mimetic of host defense peptides (HDPs), is currently in Phase 2 clinical trial as
an antibiotic drug candidate. A recent study reported that brilacidin has antiviral activity …
an antibiotic drug candidate. A recent study reported that brilacidin has antiviral activity …