Microfluidic large-scale integration: the evolution of design rules for biological automation

J Melin, SR Quake - Annu. Rev. Biophys. Biomol. Struct., 2007 - annualreviews.org
Microfluidic large-scale integration (mLSI) refers to the development of microfluidic chips
with thousands of integrated micromechanical valves and control components. This …

Micro total analysis systems. Latest advancements and trends

PS Dittrich, K Tachikawa, A Manz - Analytical chemistry, 2006 - ACS Publications
The area of micro total analysis systems (μTAS), also called “lab on a chip”, miniaturized or
microfluidic analysis systems, is a rapidly developing field. During the last several years, we …

Microfluidic synthesis of nanomaterials

Y Song, J Hormes, CSSR Kumar - small, 2008 - Wiley Online Library
An overview of the current information and analyses on the microfluidic synthesis of different
types of nanomaterial, including metallic and silica nanoparticles and quantum dots, is …

3D-printed supercapacitor-powered electrochemiluminescent protein immunoarray

K Kadimisetty, IM Mosa, S Malla… - Biosensors and …, 2016 - Elsevier
Herein we report a low cost, sensitive, supercapacitor-powered electrochemiluminescent
(ECL) protein immunoarray fabricated by an inexpensive 3-dimensional (3D) printer. The …

Development and multiplexed control of latching pneumatic valves using microfluidic logical structures

WH Grover, RHC Ivester, EC Jensen, RA Mathies - Lab on a Chip, 2006 - pubs.rsc.org
Novel latching microfluidic valve structures are developed, characterized, and controlled
independently using an on-chip pneumatic demultiplexer. These structures are based on …

Characterization and resolution of evaporation-mediated osmolality shifts that constrain microfluidic cell culture in poly (dimethylsiloxane) devices

YS Heo, LM Cabrera, JW Song, N Futai… - Analytical …, 2007 - ACS Publications
Evaporation is a critical problem when handling submicroliter volumes of fluids. This paper
characterizes this problem as it applies to microfluidic cell culture in poly (dimethylsiloxane) …

Control and measurement of the phase behavior of aqueous solutions using microfluidics

J Shim, G Cristobal, DR Link, T Thorsen… - Journal of the …, 2007 - ACS Publications
A microfluidic device denoted the Phase Chip has been designed to measure and
manipulate the phase diagram of multicomponent fluid mixtures. The Phase Chip exploits …

Micro-and nanofluidic systems for high-throughput biological screening

J Hong, JB Edel, AJ Demello - Drug discovery today, 2009 - Elsevier
High-throughput screening (HTS) is a method of scientific experimentation widely used in
drug discovery and relevant to the fields of biology. The development of micro-and …

Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays

AL Paguirigan, DJ Beebe - Bioessays, 2008 - Wiley Online Library
Microscale techniques have been applied to biological assays for nearly two decades, but
haven't been widely integrated as common tools in biological laboratories. The significant …

High-density microfluidic arrays for cell cytotoxicity analysis

Z Wang, MC Kim, M Marquez, T Thorsen - Lab on a Chip, 2007 - pubs.rsc.org
In this paper, we report on the development of a multilayer elastomeric microfluidic array
platform for the high-throughput cell cytotoxicity screening of mammalian cell lines …