Pathogenesis of central and complex sleep apnoea

JE Orr, A Malhotra, SA Sands - Respirology, 2017 - Wiley Online Library
Central sleep apnoea (CSA)–the temporary absence or diminution of ventilatory effort during
sleep–is seen in a variety of forms including periodic breathing in infancy and healthy adults …

Treatment-emergent central apnea: physiologic mechanisms informing clinical practice

S Zeineddine, MS Badr - Chest, 2021 - Elsevier
The purpose of this review was to describe our management approach to patients with
treatment-emergent central sleep apnea (TECSA). The emergence of central sleep apnea …

Research priorities for patients with heart failure and central sleep apnea. An official American Thoracic Society research statement

JE Orr, I Ayappa, DJ Eckert, JL Feldman… - American Journal of …, 2021 - atsjournals.org
Background: Central sleep apnea (CSA) is common among patients with heart failure and
has been strongly linked to adverse outcomes. However, progress toward improving …

Ventilatory control sensitivity in patients with obstructive sleep apnea is sleep stage dependent

SA Landry, C Andara, PI Terrill, SA Joosten, P Leong… - Sleep, 2018 - academic.oup.com
Abstract Study Objectives The severity of obstructive sleep apnea (OSA) is known to vary
according to sleep stage; however, the pathophysiology responsible for this robust …

Breathing rate variability in obstructive sleep apnea during wakefulness

A Pal, F Martinez, MA Akey, RS Aysola… - Journal of Clinical …, 2022 - jcsm.aasm.org
Study Objectives: Obstructive sleep apnea (OSA) is defined by pauses in breathing during
sleep, but daytime breathing dysregulation may also be present. Sleep may unmask …

Sex-related differences in loop gain during high-altitude sleep-disordered breathing

JD Bird, SA Sands, RM Alex, CLH Shing… - Annals of the …, 2023 - atsjournals.org
Rationale: Central sleep apnea (CSA) is pervasive during sleep at high altitude,
disproportionately impacting men and associated with increased peripheral …

Resonance as the mechanism of daytime periodic breathing in patients with heart failure

SA Sands, Y Mebrate, BA Edwards… - American journal of …, 2017 - atsjournals.org
Rationale: In patients with chronic heart failure, daytime oscillatory breathing at rest is
associated with a high risk of mortality. Experimental evidence, including exaggerated …

Incident Cheyne-Stokes respiration occurring in CPAP-treated patients and cardiovascular risk: a 2-years prospective follow-up (The Alertapnee study)

A Prigent, J Texereau, S Bailly, R Gervais… - Respiratory …, 2025 - Springer
The Alertapnée study followed 555 adults with obstructive sleep apnea treated with CPAP
and found that the occurrence of Cheyne-Stokes respiration (CSR) was linked to a 14-fold …

[HTML][HTML] A mathematical model of Cheyne-Stokes or periodic breathing

JB Delos - Mathematical Biosciences, 2024 - Elsevier
Abstract Cheyne-Stokes Breathing is a periodic cycle of apnea followed by hyperventilation.
A theory of this phenomenon is developed based on a minimal set of physiological …

Stable breathing in patients with obstructive sleep apnea is associated with increased effort but not lowered metabolic rate

CM de Melo, L Taranto-Montemurro, JP Butler… - Sleep, 2017 - academic.oup.com
Study objectives In principle, if metabolic rate were to fall during sleep in a patient with
obstructive sleep apnea (OSA), ventilatory requirements could be met without increased …