Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining
DA Ramsden, J Carvajal-Garcia… - Nature reviews Molecular …, 2022 - nature.com
Cellular pathways that repair chromosomal double-strand breaks (DSBs) have pivotal roles
in cell growth, development and cancer. These DSB repair pathways have been the target of …
in cell growth, development and cancer. These DSB repair pathways have been the target of …
R-loops as Janus-faced modulators of DNA repair
A Marnef, G Legube - Nature cell biology, 2021 - nature.com
R-loops are non-B DNA structures with intriguing dual consequences for gene expression
and genome stability. In addition to their recognized roles in triggering DNA double-strand …
and genome stability. In addition to their recognized roles in triggering DNA double-strand …
Loop extrusion as a mechanism for formation of DNA damage repair foci
The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome
integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment …
integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment …
Chromatin compartmentalization regulates the response to DNA damage
The DNA damage response is essential to safeguard genome integrity. Although the
contribution of chromatin in DNA repair has been investigated,, the contribution of …
contribution of chromatin in DNA repair has been investigated,, the contribution of …
[HTML][HTML] Histone ubiquitination: an integrative signaling platform in genome stability
F Mattiroli, L Penengo - Trends in Genetics, 2021 - cell.com
Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
53BP1 regulates heterochromatin through liquid phase separation
L Zhang, X Geng, F Wang, J Tang, Y Ichida… - Nature …, 2022 - nature.com
Human 53BP1 is primarily known as a key player in regulating DNA double strand break
(DSB) repair choice; however, its involvement in other biological process is less well …
(DSB) repair choice; however, its involvement in other biological process is less well …
Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization
Nuclear actin-based movements have been shown to orchestrate clustering of DNA double-
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …
TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening
CRISPR/Cas9 gene editing can inactivate genes in a precise manner. This process involves
DNA double-strand breaks (DSB), which may incur a loss of cell fitness. We hypothesize that …
DNA double-strand breaks (DSB), which may incur a loss of cell fitness. We hypothesize that …
Structural variations in cancer and the 3D genome
F Dubois, N Sidiropoulos, J Weischenfeldt… - Nature Reviews …, 2022 - nature.com
Structural variations (SVs) affect more of the cancer genome than any other type of somatic
genetic alteration but difficulties in detecting and interpreting them have limited our …
genetic alteration but difficulties in detecting and interpreting them have limited our …
[HTML][HTML] A meta-analysis of reversion mutations in BRCA genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistance
L Tobalina, J Armenia, E Irving, MJ O'Connor… - Annals of …, 2021 - Elsevier
Background Germline mutations in the BRCA1 or BRCA2 (BRCA) genes predispose to
hereditary breast and ovarian cancer and, mostly in the case of BRCA2, are also prevalent …
hereditary breast and ovarian cancer and, mostly in the case of BRCA2, are also prevalent …