Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …

Extracellular thiol/disulfide redox environments are highly regulated in healthy individuals.
The major thiol/disulfide redox couple in human plasma is cysteine (Cys) and its disulfide …

The redox proteome consists of reversible and irreversible covalent modifications that link
redox metabolism to biologic structure and function. These modifications, especially of Cys …

The pathophysiology of multiple sclerosis (MS) involves several components: redox,
inflammatory/autoimmune, vascular, and neurodegenerative. All of them are supported by …

Reactive oxygen species (ROS) are the key mediators of pathogenesis in cardiovascular
diseases. Members of the thioredoxin superfamily take an active part in scavenging reactive …

Oxidative stresses are largely mediated by intracellular protein oxidations by reactive
oxygen species (ROS). Host cells are equipped with antioxidants that scavenge ROS. The …

Macrophage migration inhibitory factor (MIF) is a multifunctional protein that exhibits an
intrinsic thiol protein oxidoreductase activity and proinflammatory activities. In the present …

Background & Aims: Thioredoxin-1 (TRX) is a small multifunctional protein with antioxidative
and redox-regulating functions. In this study, we investigated the significance of TRX in …

Macrophage migration inhibitory factor (MIF) is an evolutionary conserved 12.5-kDa protein
mediator with multiple functions in innate and acquired immunity. Upon leaderless secretion …

Apoptosis is a morphologically distinct form of cell death involved in many physiological and
pathological processes. The regulation of Fas/Apo-1 involved in membrane-mediated …