Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

Systemic lupus erythematosus (SLE) is a prime example of how the interplay between
genetic and environmental factors can trigger systemic autoimmunity, particularly in young …

Objective Systemic lupus erythematosus (SLE), an autoimmune disorder, has been
associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain …

Three-dimensional (3D) genomics is an emerging field of research that investigates the
relationship between gene regulatory function and the spatial structure of chromatin …

TNFAIP3/A20 is a prominent autoimmune disease risk locus that is correlated with
hypomorphic TNFAIP3 expression and exhibits complex chromatin architecture with over 30 …

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases and affects
almost 1% of the population. Differentiated embryo-chondrocyte expressed gene-1 (DEC1) …

Abstract Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disease that
arises from a dynamic interplay between genetics and environmental triggers. The advent of …

Immune-mediated diseases (IMDs) are complex pathologies that are strongly influenced by
environmental and genetic factors. Associations between genetic loci and susceptibility to …

For a long time, genetic variations have been considered primary risk factors predisposing to
systemic lupus erythematosus (SLE). However, alterations of DNA sequence in the genome …

Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with
nearly 100 susceptibility loci-. Nevertheless, these loci only partially explain SLE heritability …