Changes in lipids composition and metabolism in colorectal cancer: a review

A Pakiet, J Kobiela, P Stepnowski, T Sledzinski… - Lipids in health and …, 2019 - Springer
Altered metabolism of lipids is currently considered a hallmark characteristic of many
malignancies, including colorectal cancer (CRC). Lipids are a large group of metabolites …

Metabolic reprogramming of colorectal cancer cells and the microenvironment: implication for therapy

M Nenkov, Y Ma, N Gaßler, Y Chen - International journal of molecular …, 2021 - mdpi.com
Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …

Micropeptide ASAP encoded by LINC00467 promotes colorectal cancer progression by directly modulating ATP synthase activity

Q Ge, D Jia, D Cen, Y Qi, C Shi, J Li… - The Journal of …, 2021 - Am Soc Clin Investig
Emerging evidence has shown that open reading frames inside long noncoding RNAs
(lncRNAs) could encode micropeptides. However, their roles in cellular energy metabolism …

Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy

G Wang, Y Yu, YZ Wang, JJ Wang… - Journal of cellular …, 2019 - Wiley Online Library
Increased risk of colorectal cancer (CRC) is associated with altered intestinal microbiota as
well as short‐chain fatty acids (SCFAs) reduction of output The energy source of colon cells …

Mechanism of apoptosis induced by curcumin in colorectal cancer

NI Ismail, I Othman, F Abas, N H. Lajis… - International journal of …, 2019 - mdpi.com
Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …

The colorectal cancer microbiota alter their transcriptome to adapt to the acidity, reactive oxygen species, and metabolite availability of gut microenvironments

MTF Lamaudière, R Arasaradnam, GD Weedall… - Msphere, 2023 - Am Soc Microbiol
The gut microbiome is implicated in the pathology of colorectal cancer (CRC). However, the
mechanisms by which the microbiota actively contribute to disease onset and progression …

HEARTSVG: a fast and accurate method for identifying spatially variable genes in large-scale spatial transcriptomics

X Yuan, Y Ma, R Gao, S Cui, Y Wang, B Fa… - Nature …, 2024 - nature.com
Identifying spatially variable genes (SVGs) is crucial for understanding the spatiotemporal
characteristics of diseases and tissue structures, posing a distinctive challenge in spatial …

Adenylate kinase and metabolic signaling in cancer cells

A Klepinin, S Zhang, L Klepinina… - Frontiers in …, 2020 - frontiersin.org
A hallmark of cancer cells is the ability to rewire their bioenergetics and metabolic signaling
circuits to fuel their uncontrolled proliferation and metastasis. Adenylate kinase (AK) is the …

Targeting altered energy metabolism in colorectal cancer: oncogenic reprogramming, the central role of the TCA cycle and therapeutic opportunities

C Neitzel, P Demuth, S Wittmann, J Fahrer - Cancers, 2020 - mdpi.com
Colorectal cancer (CRC) is among the most frequent cancer entities worldwide. Multiple
factors are causally associated with CRC development, such as genetic and epigenetic …

[HTML][HTML] Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis

Y Ma, M Nenkov, Y Chen, AT Press… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Fatty acids are energy substrates and cell components which participate in regulating signal
transduction, transcription factor activity and secretion of bioactive lipid mediators. The acyl …