The nitrogen–nitrogen bond is a core feature of diverse functional groups like hydrazines,
nitrosamines, diazos, and pyrazoles. Such functional groups are found in> 300 known …

Currently, the tropics harbor a wide variety of crops to feed the global population. Rapid
population expansion and the consequent major demand for food and agriculture-based …

Nonheme iron-dependent enzymatic reactions play crucial roles in building and modifying
bioactive organic molecules in all major classes of natural product pathways. While the …

Burkholderia bacteria are multifaceted organisms that are ecologically and metabolically
diverse. The Burkholderia genus has gained prominence because it includes human …

l-Alanosine is a diazeniumdiolate (N-nitrosohydroxylamine) antibiotic that inhibits MTAP-
deficient tumor cells by blocking de novo adenine biosynthesis. Previous work revealed the …

Triacsins are an intriguing class of specialized metabolites possessing a conserved N-
hydroxytriazene moiety not found in any other known natural products. Triacsins are notable …

Nitrogen–nitrogen bond-containing functional groups are rare, but they are found in a
considerably wide class of natural products. Recent clarifications of the biosynthetic routes …

The Pseudomonas quinolone signal (PQS) is a multifunctional quorum sensing molecule of
key importance to P. aeruginosa. Here, we report that the lytic Pseudomonas bacterial virus …

Highlights•Approaches used include RecET recombination, CRISPR–Cas9, and transposon
mutagenesis.•RecET-like recombinases and CRISPR–Cas systems were identified in …

Cystic fibrosis (CF) is an autosomal recessive genetic disorder which leads to the secretion
of a viscous mucus layer on the respiratory epithelium that facilitates colonization by various …