The relation between alterations in chromatin structure and changes in gene expression
during cell differentiation has served as a paradigm to understand the link between genome …

The nuclear envelope (NE) is connected to the different types of cytoskeletal elements by
linker of nucleoskeleton and cytoskeleton (LINC) complexes. LINC complexes exist from …

Fitness landscapes describe the genotype-fitness relationship and represent major
determinants of evolutionary trajectories. However, the vast genotype space, coupled with …

How repetitive elements, epigenetic modifications, and architectural proteins interact
ensuring proper genome expression remains poorly understood. Here, we report regulatory …

In neurons, the timely and accurate expression of genes in response to synaptic activity
relies on the interplay between epigenetic modifications of histones, recruitment of …

Despite its evolutionarily conserved function in controlling DNA replication, the
chromosomal binding sites of the budding yeast Rif1 protein are not well understood. Here …

tRNAs are encoded by RNA polymerase III-transcribed genes that reside at seemingly
random intervals along the chromosomes of budding yeast. Existing evidence suggests that …

Recent findings provide evidence that tDNAs function as chromatin insulators from yeast to
humans. TFIIIC, a transcription factor that interacts with the B-box in tDNAs as well as …

In vertebrates, SMARCAD1 participates in transcriptional regulation, heterochromatin
maintenance, DNA repair, and replication. The molecular basis underlying its involvement in …

tRNA genes (tDNAs) have been known to have barrier insulator function in budding yeast,
Saccharomyces cerevisiae, for over a decade. tDNAs also play a role in genome …