Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

Lipopeptides are amphiphilic peptides in which an aliphatic chain is attached to either the C
or N terminus of peptides. Their self-assembly—into micelles, vesicles, nanotubes, fibres or …

The lipopeptide daptomycin is used as an antibiotic to treat severe infections with gram-
positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug …

Biofilm infection has a high prevalence in chronic wounds and can delay wound healing.
Current treatment using debridement and antibiotic administration imposes a significant …

The polymyxin and lipopeptide classes of antibiotics are membrane-targeting drugs of last
resort used to treat infections caused by multi-drug-resistant pathogens. Despite similar …

Cationic and ionizable cationic lipids are broadly applied as auxiliary agents, but their use is
associated with adverse effects. If these excipients are rapidly degraded to endogenously …

Although metals are essential for the molecular machineries of life, systematic methods for
discovering metal–small molecule complexes from biological samples are limited. Here, we …

Daptomycin is a calcium-dependent cyclic lipodepsipeptide derived from the soil saprotroph
Streptomyces roseosporus, and its antibiotic properties make it a key agent for treatment of …

Covering: 2015 to 2022 Staphylococcus aureus (S. aureus) is responsible for several
community and hospital-acquired infections with life-threatening complications such as …

Multidrug-resistant bacteria pose a serious global health threat as antibiotics are
increasingly losing their clinical efficacy. A molecular level understanding of the mechanism …