Overuse and misuse of antibiotics have resulted in wide antibiotic resistance in bacteria. In
this study, surface-enhanced Raman spectroscopy (SERS) was used to rapidly characterize …

Geometry optimization, superimposition searches and conformational analysis carried on
several lactam antibiotics show that reactivity with the active-site serine penicillin-binding …

The docking of penicillins to a computer model of the active site of the penicillin-binding
protein of Streptomyces R61 produces structures that exhibit a four-centred interaction …

Les composés mentionnés dans le titre sont des acides aminés dont l'atome d'azote est
compris dans un hydroxamate cyclique à six chaînons portant un groupe hydroxyle en …

A set of parameters, termed MMPEN, has been determined for the bicyclic nucleus of
penicillin, which, in conjunction with the appropriate parameters from MMPEP and the …

Herein, we present theoretical results on the conformational properties of benzylpenicillin,
which are characterized by means of quantum chemical calculations (MP2/6‐31G* and …

A spin-labeled penicillin derivative has been synthesized by acylation of the amino nitrogen
of 6-aminopenicillanic acid with the nitroxyl spin-label 2, 2, 5, 5-tetramethyl-l-oxypyrroline-3 …

2, 2-Dimethyl-3-(2′-hydroxypropyl)-5-carboxy-Δ3-1, 4-thiazine (1) is a designed
antibacterial agent. Based on an analysis of how penicillin complexes to and reacts with a …

β-Lactam compounds act on penicillin-recognizing enzymes via acylation of the hydroxyl
group of an active site serine. When the resulting acyl enzyme is kinetically stable, as in the …

On discute des activités antibactériennes relatives des pénicillines et des céphalosporines
en fonction de leurs facilités relatives de se complexer à et de réagir avec les protéines qui …