Potential uses, limitations, and basic procedures of micronuclei and nuclear abnormalities in buccal cells

O Torres-Bugarín, MG Zavala-Cerna, A Nava… - Disease …, 2014 - Wiley Online Library
The use of biomarkers as tools to evaluate genotoxicity is increasing recently. Methods that
have been used previously to evaluate genomic instability are frequently expensive …

DNA damage in obesity: Initiator, promoter and predictor of cancer

M Usman, EV Volpi - Mutation Research/Reviews in Mutation Research, 2018 - Elsevier
Epidemiological evidence linking obesity with increased risk of cancer is steadily growing,
although the causative aspects underpinning this association are only partially understood …

Micronuclei and disease–Report of HUMN project workshop at Rennes 2019 EEMGS conference

M Fenech, N Holland, M Kirsch-Volders… - … /Genetic Toxicology and …, 2020 - Elsevier
Abstract The “Micronuclei and Disease” workshop was organized by the HUMN Project
consortium and hosted by the European Environmental Mutagen and Genomics Society at …

The association between micronucleus, nucleoplasmic bridges, and nuclear buds frequency and the degree of uterine cervical lesions

G Gashi, V Mahovlić, S Manxhuka–Kerliu… - Biomarkers, 2018 - Taylor & Francis
Background and aim: The loss of genomic stability plays an important role in
carcinogenesis. Therefore, it is imperative to use certain biomarkers of DNA damage due to …

[HTML][HTML] Association between micronucleus frequency and cervical intraepithelial neoplasia grade in Thinprep cytological test and its significance

YH Shi, BW Wang, T Tuokan, QZ Li… - International Journal of …, 2015 - ncbi.nlm.nih.gov
A micronucleus is an additional small nucleus formed due to chromosomes or chromosomal
fragments fail to be incorporated into the nucleus during cell division. In this study, we …

Association between human papillomavirus (HPV) DNA and micronuclei in normal cervical cytology

APR Cassel, RB Barcellos, CMD Silva… - … and Molecular Biology, 2014 - SciELO Brasil
The aim of the present study was to investigate the association between HPV-DNA and
micronucleus (MN) frequency in women with normal cervical cytology. A total of 158 normal …

Cytokinesis-block micronucleus assay adapted for analyzing genomic instability of human mesenchymal stem cells

DA Cornélio, JCM Tavares, TVCA Pimentel… - Stem cells and …, 2014 - liebertpub.com
Human mesenchymal stem cells (hMSCs) are multipotent cells used in cell therapy
research. One of the problems involving hMSCs is the possibility of genetic instability during …

Predictive value of micronucleus count in cervical intraepithelial neoplasia and carcinoma.

MM Ambroise, K Balasundaram… - Turkish journal of …, 2013 - search.ebscohost.com
Objective: A micronucleus is a small additional nucleus formed due to chromosomal loss or
fragmentation. The aim of this study was to assess the utility of micronucleus count as a …

Impact of infections, preneoplasia and cancer on micronucleus formation in urothelial and cervical cells: A systematic review

T Setayesh, A Nersesyan, M Kundi, M Mišík… - … Research/Reviews in …, 2021 - Elsevier
Abstract Approximately 165,000 and 311,000 individuals die annually from urothelial (UC)
and cervical (CC) cancer. The therapeutic success of these cancers depends strongly on …

Mechanisms by which genotoxins cause micronuclei and other nuclear anomalies

M Fenech - 2019 - books.rsc.org
Normal eukaryotic cells contain a single nucleus. However, abnormal small nuclei known as
micronuclei (MN), additional to the main nucleus, may occur in cells that are exposed to …