Bacteria must rapidly respond to both intracellular and environmental changes to survive.
One critical mechanism to rapidly detect and adapt to changes in environmental conditions …

Bacillus subtilis is one of the best-studied organisms. Due to the broad knowledge and
annotation and the well-developed genetic system, this bacterium is an excellent starting …

The pathogenic microorganisms affecting plant health are major and chronic threats to
sustainable food production and ecosystem stability worldwide. Currently, synthetic …

Aminoacyl-tRNA synthetases (aaRSs) are modular enzymes globally conserved in the three
kingdoms of life. All catalyze the same two-step reaction, ie, the attachment of a …

Intricate evolutionary events enabled the emergence of the full set of aminoacyl-tRNA
synthetase (aaRS) families that define the genetic code. The diversification of aaRSs has …

Pseudomonas aeruginosa is an ubiquitous gram-negative opportunistic human pathogen
which is not considered part of the human commensal gut microbiota. However, depletion of …

Isoleucyl‐tRNA synthetase (IleRS) is an essential enzyme that covalently couples isoleucine
to the corresponding tRNA. Bacterial IleRSs group in two clades, ileS1 and ileS2, the latter …

The Gram-positive model bacterium Bacillus subtilis can acquire amino acids by import, de
novo biosynthesis, or degradation of proteins and peptides. The accumulation of several …

Prolyl-tRNA synthetases (ProRSs) are unique among aminoacyl-tRNA synthetases (aaRSs)
in having two distinct structural architectures across different organisms: prokaryote-like (P …

Plant pathogens represent one of the prime threats to sustainable crop production. Till date,
synthetic agrochemicals are considered as effective tools for the management of various …