CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond

AF Russo, DL Hay - Physiological reviews, 2023 - journals.physiology.org
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

Calcitonin gene-related peptide (CGRP): a new target for migraine

AF Russo - Annual review of pharmacology and toxicology, 2015 - annualreviews.org
Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …

Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation

AC Raddant, AF Russo - Expert reviews in molecular medicine, 2011 - cambridge.org
Over the past two decades, a convergence of basic and clinical evidence has established
the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine …

Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion

Z Zhang, CS Winborn, BM de Prado… - Journal of …, 2007 - Soc Neuroscience
The neuropeptide calcitonin gene-related peptide (CGRP) from the trigeminal ganglion has
been established as a key player in the pathogenesis of migraine. In this study, we provide …

Induction of migraine-like photophobic behavior in mice by both peripheral and central CGRP mechanisms

BN Mason, EA Kaiser, A Kuburas… - Journal of …, 2017 - Soc Neuroscience
The neuropeptide calcitonin gene-related peptide (CGRP) is a key player in migraine.
Although migraine can be treated using CGRP antagonists that act peripherally, the relevant …

Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine

A Recober, A Kuburas, Z Zhang… - Journal of …, 2009 - Soc Neuroscience
Migraine is a chronic neurological disorder characterized by recurrent episodes of severe
unilateral throbbing head pain and associated symptoms, such as photophobia. Our current …

Regulation of signal transduction by calcitonin gene-related peptide receptors

CS Walker, AC Conner, DR Poyner, DL Hay - Trends in pharmacological …, 2010 - cell.com
Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine, activating its
cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct …

CGRP and migraine: could PACAP play a role too?

EA Kaiser, AF Russo - Neuropeptides, 2013 - Elsevier
Migraine is a debilitating neurological disorder that affects about 12% of the population. In
the past decade, the role of the neuropeptide calcitonin gene-related peptide (CGRP) in …

Single-cell analysis uncovers osteoblast factor growth differentiation factor 10 as mediator of vascular smooth muscle cell phenotypic modulation associated with …

KJ Brandt, F Burger, D Baptista, A Roth… - International Journal of …, 2022 - mdpi.com
(1) Background: Vascular smooth muscle cells (VSMCs) undergo a complex phenotypic
switch in response to atherosclerosis environmental triggers, contributing to atherosclerosis …

Induction of multiple photophobic behaviors in a transgenic mouse sensitized to CGRP

A Recober, EA Kaiser, A Kuburas, AF Russo - Neuropharmacology, 2010 - Elsevier
Migraine is a complex neurological disorder with a significant impact on patients and
society. Clinical and preclinical studies have established the neuropeptide calcitonin gene …