Cholesterol is a major constituent of the human brain, and the brain is the most cholesterol‐
rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain …

Cholesterol is an essential component of both the peripheral nervous system and central
nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes …

Lipoproteins in plasma transport lipids between tissues, however, only high-density
lipoproteins (HDL) appear to traverse the blood–brain barrier (BBB); thus, lipoproteins found …

RNA splicing plays a critical role in the programming of neuronal differentiation and,
consequently, normal human neurodevelopment, and its disruption may underlie …

Cerebral palsy is a sporadic disorder with multiple likely aetiologies, but frequently
considered to be caused by birth asphyxia. Genetic investigations are rarely performed in …

Members of the low-density lipoprotein (LDL) receptor gene family have a diverse set of
biological functions that transcend lipid metabolism. Lipoprotein receptors have broad …

Cortical malformations associated with defects in neuronal migration result in severe
developmental consequences including intractable epilepsy and intellectual disability …

P4‐ATP ases translocate aminophospholipids, such as phosphatidylserine (PS), to the
cytosolic leaflet of membranes. PS is highly enriched in recycling endosomes (RE s) and is …

The evolutionarily ancient low-density lipoprotein (LDL) receptor gene family represents a
class of widely expressed cell surface receptors. Since the dawn of the first primitive …

Apolipoprotein E receptor 2 (ApoER2) and VLDL receptor belong to the low density
lipoprotein receptor family and bind apolipoprotein E. These receptors interact with the …