Cytokines regulate immune responses essential for maintaining immune homeostasis, as
deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory …

Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …

Despite recent advances in cancer immunotherapy, certain tumor types, such as
Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti …

Although notable progress has been made on novel cancer treatments, the overall survival
rate and therapeutic effects are still unsatisfactory for cancer patients …

Cytokines are critical for intercellular communication in human health and disease, but the
investigation of cytokine signaling activity has remained challenging due to the short half …

The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the
immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling …

Cytokines are major regulators of innate and adaptive immunity that enable cells of the
immune system to communicate over short distances. Cytokine therapy to activate the …

Cytokines that control the immune response were shown to have efficacy in preclinical
murine cancer models. Interferon (IFN)-α is approved for treatment of hairy cell leukemia …

By virtue of their actions on NF-κB, an inflammatory nuclear transcription factor, various
cytokines have been documented to play important regulatory roles in determining cardiac …

Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …