New Findings What is the topic of this review? The manuscript collectively combines the
experimental observations from> 100 publications focusing on the regulation of cerebral …

This article presents a historical overview and an up-to-date review of hyperthermia-induced
fatigue during exercise in the heat. Exercise in the heat is associated with a …

In the past, the role of physical activity as a life-style modulating factor has been considered
as that of a tool to balance energy intake. Although it is important to avoid obesity, physical …

An influential book written by A. Mosso in the late nineteenth century proposed that fatigue
that “at first sight might appear an imperfection of our body, is on the contrary one of its most …

The G-protein-coupled lactate receptor, GPR81 (HCA1), is known to promote lipid storage in
adipocytes by downregulating cAMP levels. Here, we show that GPR81 is also present in …

In 1923, Nobel Laureate AV Hill proposed that maximal exercise performance is limited by
the development of anaerobiosis in the exercising skeletal muscles. Variants of this theory …

We conducted a systematic review and meta-regression analysis to quantify effects of
exercise on brain hemodynamics measured by near-infrared spectroscopy (NIRS). The …

While the industrialized world adopts a largely sedentary lifestyle, ultra-marathon running
races have become increasingly popular in the last few years in many countries. The ability …

Key points• Processes leading to fatigue occur within the exercising muscle (peripheral
fatigue) and the nervous system (central fatigue).• We asked whether central processes of …

Introduction Non-local muscle fatigue (NLMF) is characterized by muscle performance
impairments in a contralateral or remote non-exercised muscle (s) following a fatiguing …