Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

A review on electroporation-based intracellular delivery

J Shi, Y Ma, J Zhu, Y Chen, Y Sun, Y Yao, Z Yang, J Xie - Molecules, 2018 - mdpi.com
Intracellular delivery is a critical step in biological discoveries and has been widely utilized
in biomedical research. A variety of molecular tools have been developed for cell-based …

Recent advances in microscale electroporation

SE Choi, H Khoo, SC Hur - Chemical reviews, 2022 - ACS Publications
Electroporation (EP) is a commonly used strategy to increase cell permeability for
intracellular cargo delivery or irreversible cell membrane disruption using electric fields. In …

Recent advancements in electroporation technologies: from bench to clinic

SN Campelo, PH Huang, CR Buie… - Annual Review of …, 2023 - annualreviews.org
Over the past decade, the increased adoption of electroporation-based technologies has led
to an expansion of clinical research initiatives. Electroporation has been utilized in …

Microfluidic and nanofluidic intracellular delivery

J Hur, AJ Chung - Advanced Science, 2021 - Wiley Online Library
Innate cell function can be artificially engineered and reprogrammed by introducing
biomolecules, such as DNAs, RNAs, plasmid DNAs, proteins, or nanomaterials, into the …

Physical triggering strategies for drug delivery

T Sun, A Dasgupta, Z Zhao, M Nurunnabi… - Advanced drug delivery …, 2020 - Elsevier
Physically triggered systems hold promise for improving drug delivery by enhancing the
controllability of drug accumulation and release, lowering non-specific toxicity, and …

Combined numerical and experimental investigation of localized electroporation-based cell transfection and sampling

P Mukherjee, SSP Nathamgari, JA Kessler… - ACS …, 2018 - ACS Publications
Localized electroporation has evolved as an effective technology for the delivery of foreign
molecules into cells while preserving their viability. Consequently, this technique has …

High throughput and highly controllable methods for in vitro intracellular delivery

J Brooks, G Minnick, P Mukherjee, A Jaberi, L Chang… - Small, 2020 - Wiley Online Library
In vitro and ex vivo intracellular delivery methods hold the key for releasing the full potential
of tissue engineering, drug development, and many other applications. In recent years, there …

Nanoscale Methods for Longitudinal Extraction of Intracellular Contents

YJ Quek, A Tay - Advanced Materials, 2024 - Wiley Online Library
Longitudinal analysis of intracellular contents including gene and protein expression is
crucial for deciphering the fundamentally dynamic nature of cells. This offers invaluable …

Micro-/nanoscale electroporation

L Chang, L Li, J Shi, Y Sheng, W Lu, D Gallego-Perez… - Lab on a Chip, 2016 - pubs.rsc.org
Electroporation has been one of the most popular non-viral technologies for cell transfection.
However, conventional bulk electroporation (BEP) shows significant limitations in efficiency …