Limitless cell proliferation, evasion from apoptosis, dedifferentiation, metastatic spread and
therapy resistance: all these properties of a cancer cell contribute to its malignant phenotype …

Osteoporosis is a pathological condition characterized by an accelerated bone resorption
rate, resulting in decreased bone density and increased susceptibility to fractures …

Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide.
Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk …

Parkinson's disease (PD) is a common neurodegenerative disorder. Neuronal cell death in
PD is still poorly understood, despite a wealth of potential pathogenic mechanisms and …

Epigenetics and epigenomic medicine encompass a new science of brain and behavior that
are already providing unique insights into the mechanisms underlying brain development …

Normally post-mitotic neurons that aberrantly re-enter the cell cycle without dividing account
for a substantial fraction of the neurons that die in Alzheimer's disease (AD). We now report …

Neuroglial apoptosis and neuroinflammation play an important role in epileptogenesis. The
aim of this study is to evaluate neuronal and glial apoptosis in association with …

Although it is well established that pharmacological inhibitors of classical histone
deacetylases (HDACs) are protective in various in vivo models of neurodegenerative …

In 1960, Rita Levi-Montalcini and Barbara Booker made an observation that transformed
neuroscience: as neurons mature, they become apoptosis resistant. The following year …

Both neuroprotective and neurotoxic roles have previously been described for histone
deacetylase-1 (HDAC1). Here we report that HDAC1 expression is elevated in vulnerable …