Oxidative stress and mitochondrial dysfunction associated with peripheral neuropathy in type 1 diabetes
E Eftekharpour, P Fernyhough - Antioxidants & Redox Signaling, 2022 - liebertpub.com
Significance: This review highlights the many intracellular processes generating reactive
oxygen species (ROS) in the peripheral nervous system in the context of type 1 diabetes …
oxygen species (ROS) in the peripheral nervous system in the context of type 1 diabetes …
Neurological implications of COVID-19: role of redox imbalance and mitochondrial dysfunction
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 or COVID-19 has been
declared as a pandemic disease by the World Health Organization (WHO). Globally, this …
declared as a pandemic disease by the World Health Organization (WHO). Globally, this …
Piceatannol promotes neuroprotection by inducing mitophagy and mitobiogenesis in the experimental diabetic peripheral neuropathy and hyperglycemia-induced …
Abstract Piceatannol (PCN), a SIRT1 activator, regulates multiple oxidative stress
mechanism and has anti-inflammatory potential in various inflammatory conditions …
mechanism and has anti-inflammatory potential in various inflammatory conditions …
Cannabidiol loaded extracellular vesicles sensitize triple-negative breast cancer to doxorubicin in both in-vitro and in vivo models
N Patel, N Kommineni, SK Surapaneni… - International journal of …, 2021 - Elsevier
Abstract Extracellular Vesicles (EVs) were isolated from human umbilical cord mesenchymal
stem cells (hUCMSCs) and were further encapsulated with cannabidiol (CBD) through …
stem cells (hUCMSCs) and were further encapsulated with cannabidiol (CBD) through …
Role of Cannabidiol and Tetrahydrocannabivarin on Paclitaxel-induced neuropathic pain in rodents
The purpose of this study was to evaluate if phytocannabinoids, synthetic cannabidiol
(CBD), and tetrahydrocannabivarin (THCV), and their combination, could protect mice from …
(CBD), and tetrahydrocannabivarin (THCV), and their combination, could protect mice from …
Cannabidiol-loaded extracellular vesicles from human umbilical cord mesenchymal stem cells alleviate paclitaxel-induced peripheral neuropathy
In cancer patients, chronic paclitaxel (PTX) treatment causes excruciating pain, limiting its
use in cancer chemotherapy. The neuroprotective potential of synthetic cannabidiol (CBD) …
use in cancer chemotherapy. The neuroprotective potential of synthetic cannabidiol (CBD) …
Carvacrol abates NLRP3 inflammasome activation by augmenting Keap1/Nrf-2/p62 directed autophagy and mitochondrial quality control in neuropathic pain
VK Arruri, C Gundu, AK Kalvala… - Nutritional …, 2022 - Taylor & Francis
Objectives: We aimed to evaluate the effect of carvacrol (CRC), a phenolic monoterpene
with high nutritional value on NLRP3 activation against chronic constriction injury (CCI) of …
with high nutritional value on NLRP3 activation against chronic constriction injury (CCI) of …
Anticancer and chemosensitization effects of cannabidiol in 2D and 3D cultures of TNBC: Involvement of GADD45α, integrin-α5,-β5,-β1, and autophagy
To date, promising therapy for triple negative breast cancer (TNBC) remains a serious
concern clinically because of poor prognosis, resistance, and recurrence. Herein, anti …
concern clinically because of poor prognosis, resistance, and recurrence. Herein, anti …
The role of Cannabidiol and tetrahydrocannabivarin to overcome doxorubicin resistance in MDA-MB-231 xenografts in athymic nude mice
The significant resistance to currently available chemotherapeutics makes treatment for
TNBC a key clinical concern. Herein, we studied the anti-cancer potentials of synthetic …
TNBC a key clinical concern. Herein, we studied the anti-cancer potentials of synthetic …
Mitochondrial unfolded protein response: a novel pathway in metabolism and immunity
L Zhu, X Luo, N Fu, L Chen - Pharmacological Research, 2021 - Elsevier
Mitochondrial unfolded protein response (mitoUPR) is a mitochondria stress response to
maintain mitochondrial proteostasis during stress. Increasing evidence suggests that …
maintain mitochondrial proteostasis during stress. Increasing evidence suggests that …