Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Discovery of a relict chloroplast (the apicoplast) in malarial parasites presented new
opportunities for drug development. The apicoplast–although no longer photosynthetic–is …

This is the third edition of this advanced textbook, written with two major objectives in mind.
One is to provide an advanced textbook covering the major areas in the fields of lipid …

Emergence of multidrug-resistant bacteria causes an urgent need for new generation of
antibiotics, which may have a different mechanism of inhibition or killing action from the …

The malaria parasite, Plasmodium falciparum, harbours a relict plastid known as the
'apicoplast'. The discovery of the apicoplast ushered in an exciting new prospect for drug …

Plasmodium parasites are unicellular eukaryotes that undergo a series of remarkable
morphological transformations during the course of a multistage life cycle spanning two …

The type II fatty acid synthase consists of a series of individual enzymes, each encoded by a
separate gene, that catalyze discrete steps in chain elongation. The formation of fatty acids …

Many anti-bacterial drugs inhibit growth of malaria parasites by targeting their bacterium-
derived endosymbiotic organelles, the mitochondrion and plastid. Several of these drugs are …

Identification of novel targets for the development of more effective antimalarial drugs and
vaccines is a primary goal of the Plasmodium genome project. However, deciding which …

SUMMARY Lipoic acid [(R)-5-(1, 2-dithiolan-3-yl) pentanoic acid] is an enzyme cofactor
required for intermediate metabolism in free-living cells. Lipoic acid was discovered nearly …