The mechanisms and roles of selective autophagy in mammals

JNS Vargas, M Hamasaki, T Kawabata… - … reviews Molecular cell …, 2023 - nature.com
Autophagy is a process that targets various intracellular elements for degradation.
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …

Mitochondria in health, disease, and aging

JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Mitochondrial dynamics in health and disease: mechanisms and potential targets

W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

[HTML][HTML] Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation

Y Lu, Z Li, S Zhang, T Zhang, Y Liu, L Zhang - Theranostics, 2023 - ncbi.nlm.nih.gov
Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …

Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases

RA Nixon, DC Rubinsztein - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

Mitophagy in human health, ageing and disease

A Picca, J Faitg, J Auwerx, L Ferrucci, D D'Amico - Nature Metabolism, 2023 - nature.com
Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease

A Li, M Gao, B Liu, Y Qin, L Chen, H Liu, H Wu… - Cell death & …, 2022 - nature.com
Mitochondria are highly dynamic organelles that participate in ATP generation and involve
calcium homeostasis, oxidative stress response, and apoptosis. Dysfunctional or damaged …

Molecular mechanisms and physiological functions of mitophagy

M Onishi, K Yamano, M Sato, N Matsuda… - The EMBO …, 2021 - embopress.org
Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

[HTML][HTML] Autophagy in inflammation, infection, and immunometabolism

V Deretic - Immunity, 2021 - cell.com
Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …

NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …