The ventral tegmental area (VTA) is well known for regulating reward consumption, learning,
memory, and addiction behaviors through mediating dopamine (DA) release in downstream …

Hippocampal place cells support reward-related spatial memories by forming a cognitive
map that over-represents reward locations. The strength of these memories is modulated by …

Biological sex disparities manifest at various stages of drug addiction, including craving,
substance abuse, abstinence, and relapse. These discrepancies are underpinned by …

Neuromodulatory inputs to the hippocampus play pivotal roles in modulating synaptic
plasticity, shaping neuronal activity, and influencing learning and memory. Recently, it has …

Learning and memory mainly rely on correct synaptic function in the hippocampus and other
brain regions. In Parkinson's disease, subtle cognitive deficits may even precede motor …

Background Besides the established role of dopamine neurons and projections in
nociceptive stimuli, the involvement of ventral tegmental area (VTA) glutamatergic …

Aim Alcohol abuse is a significant causative factor of death worldwide. The Notch1 signaling
pathway is involved in alcohol tolerance, withdrawal and dependence. Agomelatine is a …

Excitatory pyramidal (PYR) cell activation of interneurons (INT) produces network
oscillations that underlie cognitive processes in the hippocampus (CA1). Neural projections …

Navigating toward destinations with rewards is a common behavior among animals. The
ventral tegmental area (VTA) has been shown to be responsible for reward coding and …

The hippocampus has been implicated in the processing and storage of aversive memories
but the precise mechanisms by which these memories persist in time remain elusive. We …