Abstract Galectin (Gal)-3 is a β-galactoside-binding lectin emerging as a key player in
cardiac, hepatic, renal, and pulmonary fibrosis and inflammation, respiratory infections …

Perivascular niches in the kidney comprise heterogeneous cell populations, including
pericytes and fibroblasts, with distinct functions. These perivascular cells have crucial roles …

Inclusion body myositis (IBM) is unique across the spectrum of idiopathic inflammatory
myopathies (IIM) due to its distinct clinical presentation and refractoriness to current …

Circulating proteomic signatures of age are closely associated with aging and age-related
diseases; however, the utility of changes in secreted proteins in identifying therapeutic …

Dysfunction of mesangial cells plays a major role in the pathogenesis of diabetic kidney
disease (DKD), the leading cause of kidney failure. However, the underlying molecular …

Studies have highlighted the significant involvement of kidney pericytes in renal fibrosis.
Kidney pericytes, classified as interstitial mesenchymal cells, are extensively branched …

Background In spite of new treatments, the incidence of type 2 diabetes (T2D) and its
morbidities continue to rise. The key feature of T2D is resistance of adipose tissue and other …

Fibrosis is a universal aging-related pathological process in the different organ, but is
actually a self-repair excessive response. To date, it still remains a large unmet therapeutic …

Long-term peritoneal dialysis (PD) causes structural and functional alterations of the
peritoneal membrane. Peritoneal deterioration and fibrosis are multicellular and …

CD248 (endosialin) belongs to a glycoprotein family that also includes thrombomodulin
(CD141), CLEC14A, and CD93 (AA4) stem cell markers. We analyzed the regulated …