Mechanisms for estrogen receptor expression in human cancer

H Hua, H Zhang, Q Kong, Y Jiang - Experimental hematology & oncology, 2018 - Springer
Estrogen is a steroid hormone that has critical roles in reproductive development, bone
homeostasis, cardiovascular remodeling and brain functions. However, estrogen also …

Critical role of estrogen in the progression of chronic liver diseases

D Ezhilarasan - Hepatobiliary & Pancreatic Diseases International, 2020 - Elsevier
Background Estrogens regulate sexual function and also have a significant role in various
pathophysiological processes. Estrogens have a non-reproductive role as the modulators of …

Sex disparities in presentation and prognosis of 1110 patients with hepatocellular carcinoma

NE Rich, CC Murphy, AC Yopp, J Tiro… - Alimentary …, 2020 - Wiley Online Library
Background Although sex disparities in hepatocellular carcinoma (HCC) incidence have
been well described, there are limited data examining sex disparities in HCC prognosis. Aim …

The clinical significance of microvascular invasion in the surgical planning and postoperative sequential treatment in hepatocellular carcinoma

W Wang, Y Guo, J Zhong, Q Wang, X Wang, H Wei… - Scientific Reports, 2021 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common and most lethal malignant
tumors in the world. Microvascular invasion (MVI) is a major risk factor for survival outcomes …

Alcohol and hepatocellular carcinoma

H Matsushita, A Takaki - BMJ open gastroenterology, 2019 - bmjopengastro.bmj.com
Background Alcohol is classified as a Group 1 carcinogen by the International Agency for
Research on Cancer because it induces hepatocellular carcinoma (among other cancers) in …

The G Protein-Coupled Estrogen Receptor (GPER): a critical therapeutic target for cancer

KA Hall, EJ Filardo - Cells, 2023 - mdpi.com
Estrogens have been implicated in the pathogenesis of various cancers, with increasing
concern regarding the overall rising incidence of disease and exposure to environmental …

Retinoic acids in the treatment of most lethal solid cancers

L Costantini, R Molinari, B Farinon… - Journal of clinical …, 2020 - mdpi.com
Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA)
concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 …

Emerging role of exosomal microRNA in liver cancer in the era of precision medicine; potential and challenges

T El Hayek, OA Alnaser-Almusa… - Frontiers in Molecular …, 2024 - frontiersin.org
Exosomal microRNAs (miRNAs) have great potential in the fight against hepatocellular
carcinoma (HCC), the fourth most common cause of cancer-related death worldwide. In this …

[HTML][HTML] Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma

F Villarruel-Melquiades… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most lethal malignant tumours worldwide. The
mortality-to-incidence ratio is up to 91.6% in many countries, representing the third leading …

Epidemiology of liver cancer in Africa: current and future trends

E Okeke, PM Davwar, L Roberts… - Seminars in liver …, 2020 - thieme-connect.com
Hepatocellular carcinoma (HCC) is a disease of global public health significance with
mortality on the rise, despite the preventable nature of its risk factors especially in Africa. It is …