Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis

TV Pereira, P Jüni, P Saadat, D Xing, L Yao, P Bobos… - bmj, 2022 - bmj.com
Objective To evaluate the effectiveness and safety of viscosupplementation for pain and
function in patients with knee osteoarthritis. Design Systematic review and meta-analysis of …

[HTML][HTML] Effects of non-steroidal anti-inflammatory drugs (NSAIDs) and gastroprotective NSAIDs on the gastrointestinal tract: a narrative review

R Sohail, M Mathew, KK Patel, SA Reddy, Z Haider… - Cureus, 2023 - ncbi.nlm.nih.gov
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for their anti-
inflammatory, antipyretic, and analgesic properties. However, their use is often associated …

Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment

T Vinikoor, GK Dzidotor, TT Le, Y Liu, HM Kan… - Nature …, 2023 - nature.com
Osteoarthritis affects millions of people worldwide but current treatments using analgesics or
anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an …

Mapping the neuroethological signatures of pain, analgesia, and recovery in mice

M Bohic, LA Pattison, ZA Jhumka, H Rossi… - Neuron, 2023 - cell.com
Ongoing pain is driven by the activation and modulation of pain-sensing neurons, affecting
physiology, motor function, and motivation to engage in certain behaviors. The complexity of …

A solid–liquid composite lubricating “nano‐snowboard” for long‐acting treatment of osteoarthritis

W Qiu, W Zhao, L Zhang, H Wang, N Li… - Advanced Functional …, 2022 - Wiley Online Library
Osteoarthritis is a chronic inflammatory disease characterized by cartilage degeneration.
Anti‐inflammatory therapy has limited effects, and effective reduction of cartilage wear …

Targeting macrophage polarization as a promising therapeutic strategy for the treatment of osteoarthritis

W Wang, Y Chu, P Zhang, Z Liang, Z Fan, X Guo… - International …, 2023 - Elsevier
Osteoarthritis (OA) is a chronic osteoarthropathy characterized by the progressive
degeneration of articular cartilage and synovial inflammation. Early OA clinical treatments …

NSAID: Current limits to prescription

T Wirth, P Lafforgue, T Pham - Joint Bone Spine, 2024 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to alleviate pain
and inflammation in conditions like arthritis, migraines, and post-operative recovery. Their …

Meniscus-inspired self-lubricating and friction-responsive hydrogels for protecting articular cartilage and improving exercise

L Liu, Y Xian, W Wang, L Huang, J Fan, W Ma, Y Li… - ACS …, 2023 - ACS Publications
Meniscus injuries are associated with the degeneration of cartilage and development of
osteoarthritis (OA). It is challenging to protect articular cartilage and improve exercise when …

Multimodal multidisciplinary management of patients with moderate to severe pain in knee osteoarthritis: a need to meet patient expectations

N Veronese, C Cooper, O Bruyère, NM Al-Daghri… - Drugs, 2022 - Springer
Knee osteoarthritis (OA) is one of the most common and disabling medical conditions. In the
case of moderate to severe pain, a single intervention may not be sufficient to allay …

Chiral nanosilica drug delivery systems stereoselectively interacted with the intestinal mucosa to improve the oral adsorption of insoluble drugs

X Chen, Y Cheng, Q Pan, L Wu, X Hao, Z Bao, X Li… - ACS …, 2023 - ACS Publications
Chiral nanoparticles (NPs) with nanoscale rough surfaces have enormous application
prospects in drug delivery. However, the stereoselective interactions between the chiral NPs …