Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths
worldwide. Although recent advances in therapeutic approaches for treating HCC have …

Liver cancer is the third leading cause of cancer-related death worldwide. Advances in
sequencing technologies have enabled the examination of liver cancer genomes at high …

Cellular diversity in tumors is a key factor for therapeutic failures and lethal outcomes of solid
malignancies. Here, we determined the single-cell transcriptomic landscape of liver cancer …

Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional
addictions that may be therapeutically exploited. Yet, the mechanisms that are ultimately …

Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are clinically
disparate primary liver cancers with etiological and biological heterogeneity. We identified …

The urea cycle (UC) is the main pathway by which mammals dispose of waste nitrogen. We
find that specific alterations in the expression of most UC enzymes occur in many tumors …

Hepatocellular carcinoma (HCC) is highly heterogeneous in nature and has been one of the
most common cancer types worldwide. To ensure repeatability of identified gene expression …

Pharmacologic perturbation projects, such as Connectivity Map (CMap) and Library of
Integrated Network-based Cellular Signatures (LINCS), have produced many perturbed …

Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and
heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs …

Background Predictive biomarkers for the recurrence of hepatocellular carcinoma (HCC)
have great benefit in the selection of treatment options, including liver transplantation (LT) …