Drug delivery to the central nervous system

E Nance, SH Pun, R Saigal, DL Sellers - Nature Reviews Materials, 2022 - nature.com
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

Interactions of nanoparticles and biosystems: microenvironment of nanoparticles and biomolecules in nanomedicine

C Auría-Soro, T Nesma, P Juanes-Velasco… - Nanomaterials, 2019 - mdpi.com
Nanotechnology is a multidisciplinary science covering matters involving the nanoscale
level that is being developed for a great variety of applications. Nanomedicine is one of …

RGD engineered dendrimer nanotherapeutic as an emerging targeted approach in cancer therapy

A Sheikh, S Md, P Kesharwani - Journal of Controlled Release, 2021 - Elsevier
A bird's eye view is now demanded in the area of cancer research to suppress the suffering
of cancer patient and mediate the lack of treatment related to chemotherapy. Chemotherapy …

Future applications of MXenes in biotechnology, nanomedicine, and sensors

A Szuplewska, D Kulpińska, A Dybko, M Chudy… - Trends in …, 2020 - cell.com
The past few years have seen significant developments in the chemistry and potential
biological applications of 2D materials. This review focuses on recent advances in the …

[HTML][HTML] Harnessing cerebrospinal fluid circulation for drug delivery to brain tissues

GN Kouzehgarani, T Feldsien, HH Engelhard… - Advanced Drug Delivery …, 2021 - Elsevier
Initially thought to be useful only to reach tissues in the immediate vicinity of the CSF
circulatory system, CSF circulation is now increasingly viewed as a viable pathway to deliver …

Engineering at the nano-bio interface: harnessing the protein corona towards nanoparticle design and function

RL Pinals, L Chio, F Ledesma, MP Landry - Analyst, 2020 - pubs.rsc.org
Unpredictable and uncontrollable protein adsorption on nanoparticles remains a
considerable challenge to achieving effective application of nanotechnologies within …

Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications …

V Agrahari, PA Burnouf, T Burnouf… - Advanced Drug Delivery …, 2019 - Elsevier
Nanocarriers (synthetic/cell-based have attracted enormous interest for various therapeutic
indications, including neurodegenerative disorders. A broader understanding of the impact …

Surface charge, glycocalyx, and blood-brain barrier function

FR Walter, AR Santa-Maria, M Mészáros… - Tissue …, 2021 - Taylor & Francis
The negative surface charge of brain microvessel endothelial cells is derived from the
special composition of their membrane lipids and the thick endothelial surface glycocalyx …

Recent advances in MXenes: new horizons in biomedical technologies

AK Tareen, K Khan, M Iqbal, S Golovynskyi… - Materials Today …, 2022 - Elsevier
Biomedicine and nanotechnology are advancing at a breakneck speed resulted in an
abundance of novel nanomaterials (NMs) based biomedical platforms. The 2D layered nano …

Effect of particle size and surface charge on nanoparticles diffusion in the brain white matter

T Yuan, L Gao, W Zhan, D Dini - Pharmaceutical Research, 2022 - Springer
Purpose Brain disorders have become a serious problem for healthcare worldwide.
Nanoparticle-based drugs are one of the emerging therapies and have shown great promise …