Recent developments in the synthesis and reactivity of isoxazoles: metal catalysis and beyond

F Hu, M Szostak - Advanced Synthesis & Catalysis, 2015 - Wiley Online Library
Isoxazoles are important five‐membered aromatic heterocycles in organic chemistry.
Recently, many exciting advances in the synthesis and functionalization of isoxazoles have …

The synthetic and therapeutic expedition of isoxazole and its analogs

N Agrawal, P Mishra - Medicinal Chemistry Research, 2018 - Springer
Isoxazole, constituting an important family of five-membered heterocycles with one oxygen
atom and one nitrogen atom at adjacent positions is of immense importance because of its …

Recent advances in isoxazole chemistry

AV Galenko, AF Khlebnikov, MS Novikov… - Russian Chemical …, 2015 - iopscience.iop.org
The preparation methods and reactions of isoxazoles are described and systematized on
the basis of analysis of the literature published from 2005 to present. In the discussion of …

tert-Butyl nitrite triggered radical cascade reaction for synthesizing isoxazoles by a one-pot multicomponent strategy

L Chen, Z Wang, H Liu, X Li, B Wang - Chemical Communications, 2022 - pubs.rsc.org
A metal-free radical cyclization/dehydrogenation cascade of alkenes with aldehydes has
been developed for the synthesis of 3, 5-disubstituted isoxazoles in a one-pot system. This …

Synthesis of 3, 5-disubstituted isoxazoles and isoxazolines in deep eutectic solvents

JM Perez, DJ Ramon - ACS Sustainable Chemistry & Engineering, 2015 - ACS Publications
The synthesis of different 3, 5-disubstituted isoxazoles and related isoxazolines using
choline chloride: urea as deep eutectic solvent (DES) in a one-pot three step reaction has …

Facile Synthesis of Disubstituted Isoxazoles from Homopropargylic Alcohol via C N Bond Formation

P Gao, HX Li, XH Hao, DP Jin, DQ Chen, XB Yan… - Organic …, 2014 - ACS Publications
A novel iron-catalyzed aerobic oxidative reaction to synthesize disubstituted isoxazoles from
homopropargylic alcohol, t-BuONO, and H2O is developed. The method provides mild …

Greener synthesis of nitrogen-containing heterocycles in water, PEG, and bio-based solvents

JF Campos, S Berteina-Raboin - Catalysts, 2020 - mdpi.com
The solvents used in chemistry are a fundamental element of the environmental
performance of processes in corporate and academic laboratories. Their influence on costs …

Harnessing the TEMPO-catalyzed aerobic oxidation for Machetti–De Sarlo reaction toward sustainable synthesis of isoxazole libraries

M Vadivelu, S Sampath, K Muthu… - The Journal of …, 2019 - ACS Publications
A practical synthesis of isoxazole/isoxazoline derivatives via Machetti–De Sarlo reaction
under sustainable conditions has been accomplished. This protocol involves the use of …

Synthesis of 5‐(Fluoromethyl)‐4, 5‐dihydroisoxazoles by Silver‐Catalyzed Oxyfluorination of Unactivated Alkenes

YY Liu, J Yang, RJ Song, JH Li - Advanced Synthesis & …, 2014 - Wiley Online Library
A new silver‐catalyzed oxyfluorination of unactivated alkenes using commercially available
Selectfluor as the fluorine source is presented. This method provides a new access to 5 …

“On water” direct catalytic vinylogous Henry (nitroaldol) reactions of isatins for the efficient synthesis of isoxazole substituted 3-hydroxyindolin-2-ones

Y Zhang, BW Wei, H Lin, L Zhang, JX Liu, HQ Luo… - Green …, 2015 - pubs.rsc.org
The first example of an “on water” direct catalytic vinylogous Henry addition of 3, 5-dialkyl-4-
nitroisoxazoles to isatins is described, giving products in excellent yields and up to excellent …